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doi: 10.2169/internalmedicine.3171-23 48 SchafferLFde FreitasCMChiapinotto CerettaAPPerozaLRde Moraes ReisEKrumBNet al

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477,478 Mechanistically, LPAR2 binds to Siva1, a proapoptotic protein activated by DNA damage, and prevents Siva1-Bcl-xL-mediated mitochondrial apoptosis by targeting Siva1 for degradation

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Concerns have been raised about using very high doses of Glutathione without appropriate monitoring

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