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Simultaneously, silybin improves endothelial dysfunctiona critical link in the onset of inflammationby lowering asymmetric dimethylarginine (ADMA) levels, thereby reversing nitric oxide synthase inhibition and increasing the bioavailability of NO, which possesses anti-inflammatory and vasodilatory functions

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Sndergrd SD, Cintin I, Kuhlman AB, Morville TH, Bergmann ML, Kjr LK, Poulsen HE, Giustarini D, Rossi R, Dela F, Helge JW