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doi: 10.1016/j.cmet.2018.04.022 286 CorzoCACondamineTLuLCotterMJYounJIChengPet al

However, the volume of the nucleus does not change significantly, there is a lack of chromatin condensation but the chromosome structure does not disappear, and the rupture of the cell membrane does not occur in the process of ferroptosis

Zhang C, Lu T, Wang GD, Ma C, Zhou YF (2016) Costunolide, an active sesquiterpene lactone, induced apoptosis via ROS-mediated ER stress and JNK pathway in human U2OS cells

It is critically involved in maintaining cellular homeostasis, mitigating oxidative stress, promoting cell survival and growth, and modulating cell death and autophagy 40