what causes melanotic macule

what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Melanotic macule. Benign. Dark spot

Name: what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Melanotic macule. Benign. Dark spot
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Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology Citalopram Induced Oral Melanotic Macules in a Female Patient and a Review of the Literature Cureus

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Numerous researches have reported that silibinin can promote the apoptosis by regulating apoptotic-related proteins (e.g., Bax, Bcl-2, and Bcl-xL) and activating Caspases in lung, colon, renal, oral, pancreatic cancers, as well as endometrial carcinoma [920, 921]

Wallensten et al., 2023)

The different types of disease-associated melanoses listed below are highly correlated with oral/perioral pigmentation and are of prime concern in a differential diagnosis: Addisons disease Peutz-Jeghers syndrome Chronic lichen planus Laugier-Hunziker syndrome Neurofibromatosis McCune-Albright syndrome Kaposi sarcoma The prognosis for oral melanotic macules is excellent, and they are followed and monitored after diagnosis through documentation and photographs/images