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My lab has found that mice with genetic mutations in core clock components, such as Clock or Bmal1, display marked dysregulation of glucose and lipid homeostasis, putting them at increased risk for obesity, insulin resistance, and fatty liver disease

The easiest way to think about it: TB-500 (Full Length) = studying the entire book Fragment 1-4 = studying the opening paragraph Fragment 17-23 = studying a specific chapter Each approach provides different insights