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They are triggered by a variety of direct or indirect pulmonary insults, and their complex pathophysiology is yet to be fully understood

Reactive oxygen species (ROS) not only induce DNA hypermethylation but also interfere with histone modifications, leading to impaired oocyte maturation and endometrial dysfunction 10,11

Intermittent claudication in peripheral arterial disease In peripheral arterial disease, atherosclerosis of the arteries that supply the lower extremities may diminish blood flow to the point that the metabolic needs of exercising muscles are not sufficiently met, thereby leading to ischemic leg or hip pain known as claudication (see the page on Intermittent Claudication in Peripheral Arterial Disease) (63)

Emerging evidence suggests that exercise may provide potential benefits during treatment and recovery, and survival in recurrent malignant glioma correlates positively with physical activity levels [265]