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Nature 556 , 332338 (2018)

Eventually, when enough thyroid tissue is attacked, the body no longer produces thyroid hormone

It is noteworthy that Pt-induced ROS production impairs antioxidant enzymes [e.g., superoxide dismutase (SOD) and catalase (CAT)] to trigger oxidative stress (Khasabova et al., 2019), which participates in the onset and progression of both acute and chronic PIPN