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Besides, ursolic acid showed similar protective effects through LKB1/AMPK pathway activation, elevating GPX4 and SLC7A11 expression while enriching Firmicutes and suppressing Bacteroidota [173]

Direct -synuclein promoter transactivation by the tumor suppressor p53

Immune balance is also influenced by broader systems involved in immune regulation and inflammation, including gut-associated lymphoid tissue (GALT) and the hypothalamic-pituitary-adrenal (HPA) axis, reinforcing the importance of addressing antioxidant capacity as part of a whole-system approach

Cells and the corresponding culture supernatants from AR/Ad cells were collected similarly to the procedures for glutamine measurement, while samples from lactate-treated cells were collected by culturing cells in glucose-free medium with 20 mM lactate incubation for 1, 2, 4, 8, 12, 24, 36, and 48 h