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In intestinal epithelial cells, PGC-1 has been observed to promote mitochondrial respiration while simultaneously suppressing antioxidant capacity, leading to the accumulation of ROS and triggering apoptosis, thereby serving as a tumor-suppressive mechanism to prevent carcinogenesis

Tesamorelin is FDA-approved for the reduction of visceral adipose tissue (VAT) in patients with HIV-associated lipodystrophy, but its clinical applications extend far beyond that indication