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In ovariectomised mice, curcumin modulated depression-like behaviours and improved the serotonin content in several brain regions by upregulating tryptophan hydroxylase-2 and 5-HT 1A/2A receptor messenger RNA (mRNA) and downregulating monoamine oxidase A mRNA in the limbic system [13]

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Moreover, oligomeric forms of A can increase oxidative stress in neurons [84, 85]

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