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Description

Lancet (2015) 386:98394

Prediction of targets of curculigoside a in osteoporosis and rheumatoid arthritis using network pharmacology and experimental verification

The increase in serum sTWEAK levels may have been because probiotic intake reduces inflammation, thereby downregulating Fn14, the only receptor for sTWEAK, which prevents sTWEAK from binding Fn14

However, because this evidence comes from a preclinical mouse study rather than a human clinical trial, these findings should be interpreted cautiously and should not be used to support direct clinical recommendations for patients with T2DM (74)