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Our study explored how cancer-related resistance could be reversed by targeting BCAA metabolism, enhancing sensitivity to radiotherapy, chemotherapy, targeted therapy, and immunotherapy

10.1016/j.bpj.2019.05.013 74 HuangS.MoX.WangJ.YeX.YuH.LiuY

Extracellular glutamate is efficiently taken up by the sodiumdependent excitatory amino acid transporters (EAAT) 1 and 2 (Todd and Hardingham 2020), while glycine uptake is mediated by the sodiumdependent transporters GlyT1 and GlyT2 (Marques et al