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"Registering with the FDA means not only can we meet the needs of a larger group of patients and serve them, because of our national licensing, but it means we're meeting good manufacturing practices," CEO Shaun Noorian said following a tour of the new center

To define a CDK11-dependent rate-limiting step in spliceosome activation, we decided to determine the precise protein composition of spliceosomes blocked by OTS964 in cells

The first layer should focus on biodistribution: local or lesion-preferring delivery is likely to yield the greatest gain in therapeutic index

In glioma, results of phase I trial NCT02454634 recently published in Nature (202) showed that topical Imiquimod combined with IDH1 peptide vaccine induced 93.3% immune responses in IDH1R132H-mutated patients while adverse effects are within grade I