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This response was caused primarily by GH hypersecretion, as expression of a GH antagonist resulted in improvement of glucose homeostasis [129, 229]

Extremely fast visible effects can be observed in body circumferences

Hepatic knockdown of GADD45 exacerbates steatohepatitis in MCD mice To investigate the role of hepatic GADD45 in steatohepatitis, C57BL/6J mice fed an MCD diet were injected with adenoviral shRNA targeting GADD45 via the tail vein, which effectively reduced hepatic GADD45 expression (Fig