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Chronic IH may also result in an imbalance in the ratio of arginase-1 (an enzyme that competes with eNOS for L-arginine) to eNOS expression, resulting in decreased NO availability, a key feature of ECD [149]

Both are powerful antioxidants, but with different profiles: the resveratrol is water-soluble and acts primarily in the aqueous compartments of the cell, while astaxanthin, being lipophilic, protects the membrane structures

High dose rate and flattening filter free irradiation can be safely implemented in clinical practice

We further demonstrate that the previously recognized ferroptosis suppressor FSP1 is the vitamin K reductase that sustains a warfarin-insensitive non-canonical vitamin K cycle that suppresses ferroptosis by maintaining VKH 2 at the expense of NAD(P)H to prevent lipid peroxidation (Fig