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Ionizable Lipids In order to overcome the limitation of cationic lipids and further improve the RNA delivery efficiency, numerous ionizable lipids with ionizable amino head groups have been developed as a critical component for the formulation of LNPs

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[4] Shukla KK et al

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Accessibility of an enzymatic ROS-generating site to di-oxygen is also a key determinant for rate of ROS production (Klinman, 2007)

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