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The oscillation activation of PARP-1 interacts with and poly(ADP-ribosyl)ates CLOCK, leading to suppressed binding of CLOCK: BMAL1 to DNA and altered circadian gene expression

CONTRAST is additionally financed by the Ministry of Economic Affairs by means of the PPP Allowance made available by the Top Sector Life Sciences & Health to stimulate public-private partnerships (LSHM17016) and was funded in part through unrestricted funding by Stryker, Medtronic, and Cerenovus

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1-3 The REIMAGINE clinical program evaluating CagriSema in adults with T2D follows previously published results from the REDEFINE clinical program, evaluating CagriSema in adults with overweight or obesity with and without T2D