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Consider baseline labs for copper and zinc and reassess if symptoms or labs shift

Together, these interconnected processes highlight the complexity of ferroptosis, which depends on the regulation of iron homeostasis, lipid peroxidation, and oxidative stress, with the NADPH oxidase system playing a key role in amplifying the damage ( Figure 1 )

The unique characteristics of central iron homeostasis and the presence of the BBB also pose therapeutic challenges

Similarly, while observational studies associate vitamin K with positive cardiovascular outcomes, randomized controlled trials showed inconsistent findings, particularly after adjusting for confounders