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Prostate cancer cells co-cultured with adipocytes increase expression of IL1- to stimulate adipocyte lipolysis in a vicious positive feedback loop that decreases prostate cancer cell sensitivity to docetaxel and upregulates prostaglandin E2 (PGE2) synthesis in adipocytes, a prostate cancer pro-survival signal (212)

This makes it safe for patients who need fat reduction support without the metabolic complications associated with growth hormone therapy

So I would say those are the couple of things that I would start with because it changes your life