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Third, many studies address anabolicandrogenic steroids as a broad category without distinguishing testosterone as an individual compound

this action not only disrupts intercellular junctions but also induces the degradation of basement membrane components, including laminin and collagen IV, further damaging the BBB (64)

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We hypothesize that the specific tumor cell killing effect of melatonin compensates for the protective effect of ferroptosis inhibition on tumor cells, thereby simultaneously achieving enhanced radiosensitivity and reduced radiation-induced injury