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In particular, PDAC cells require Gln, and supplementation of aKG with nonessential amino acids (NEAAs) rescues PDAC cells from Gln deprivation-mediated growth inhibition 11,26 , supporting the present data showing that Gln is a critical source for aKG production

This study shows that tumour tissue of origin and oncogenic drivers combine to regulate glutamine metabolism

Mutation-independent therapies can have various downstream targets that aim to improve mitochondrial respiration, reduce mitochondrial stress, inhibit or delay RGC apoptosis, and/or promote RGC survival

Instead of manifesting disaster, I manifest positive thoughts and a new sense of purpose, he says