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Differential changes in PKLR in males (decreased) and females (increased) could have significant functional consequences in liver since glycolytic inhibition (such as by decreases in PKM2) has been suggested to promote the pentose phosphate pathway to generate higher levels of NADPH

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With advances in personalized microbiota profiling and precision intervention strategies, Clostridium -based therapies are expected to overcome existing translational gaps, providing new hope for improving the prognosis of patients with intractable autoimmune diseases

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