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Glutathione serves as a first line of defense by preventing free radicals from forming and neutralizing those that do before they can damage healthy cells

Accelerated recovery: IGF-1 promotes repair and regeneration of damaged tissue, making it valuable post-injury or following intense hypertrophy training

Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

Importantly, the enzymatic activity of the Prxs is regulated by Trx1, and so the TrxR1 system plays a critical role in this regulatory system