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Acid suppression medications and metformin also reduce vitamin B12 absorption and so increase the risk of deficiency

Crosstalk between DNA damage and inflammation in the multiple steps of gastric carcinogenesis

So its been studied in inflammatory bowel diseases like Crohns disease and ulcerative colitis, ankylosing spondylitis, multiple sclerosis, lupus, psoriasis, lichen planus, type 1 diabetes, and Hashimotos [disease], fibrositis

However, research designs are increasingly rationalized, including longitudinal comparisons, time-node samples, combined clinical sample analysis, etc