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However, it is important to note that most studies to date have examined enzymatic activity under these inflammatory or lipid-loaded conditions, and its role in non-inflammatory or homeostatic macrophage states remains less well defined

10.1007/s12602-020-09663-6 80 JiangH.YanR.WangK.WangQ.ChenX.ChenL.et al (2021)

This suggests that Fragment 176-191 may influence signaling pathways or transcription factors that enhance the production of beta-3 adrenergic receptor mRNA, leading to increased synthesis of the beta-3 adrenergic receptors protein

Conclusion: ROS and oxidative stress have a significant role in the pathophysiology of SCI