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Nivel de evidencia La evidencia es limitada: sobre todo in vitro y proveniente de un mismo grupo de investigacin, sin replicacin independiente amplia

10.1002/adfm.201907066 56 RabikC

a large number of issues that cloud the interpretation of a small observed effect. Lumakras was approved under the FDAs accelerated approval pathway in May 2021

, who identified the natural compound rhein as a first-in-class, competitive inhibitor that targets the catalytic site of FTO in biochemical assays[257]