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Similar to Schwann cells, the addition of Schwann cell-derived exosomes also induces angiogenesis and osteogenesis ( In vivo observations show that when combined with 3D porous Ti6Al4V scaffolds to repair bone defect in New Zealand white rabbits, Schwann cell-derived exosomes enhance the formation of new bones in a dose-dependent manner (Wu et al., 2020)

It is supplied as a lyophilized powder in a 10mg vial requiring reconstitution before research use

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Current understanding is limited by simplified in vitro and short-term animal models and neglect of the periodontal pockets unique environment, which is characterized by fluid flow, protease activity, hypoxia, and low pH, all of which constrain local interventions