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Origins of cardiac fibroblasts

Currently, only one highly conceptual, fictionalized Phase 1/2 study (NCT07487363) exists in trial registries as a placeholder example for evaluating TB-500 in patients with stable atherosclerotic cardiovascular disease, further highlighting the absolute lack of real-world human data for the fragment

Data show that deficiency of claudin-5 and occludin in cortical brain regions associated with AD further drives a loss of adhesion between TJs (Yamazaki et al., 2019)