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The commenter argued that the 2 mL threshold is arbitrary and would result in the misclassification of numerous drugs

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Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

396 , 397 For example, and clinical trials are attempting to use the GABAergic system as a therapeutic strategy for ASD, 396 and a recent study showed that a clinically relevant selective ERK pathway inhibitor reverses the core deficits in a mouse model of autism