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However, when the assay was repeated with 5-amino-6-fluoro-1MQ, an analogue of 5-amino-1MQ that did not interfere with the NAMPT assay, no inhibition of NAMPT was observed with analogue concentrations between 30 and 600 M (data not shown)

Healthcare professionals should maintain awareness that GLP-1/GIP medicines, whilst highly effective for their intended indications, require holistic management addressing not only glycaemic control and weight but also nutritional status and overall metabolic health

Acknowledgements The work was funded by the Engineering and Physical Sciences Research Council International Centre-to-Centre grant no EP/S030336/1

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