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Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer

Clinical trialsand other types of clinical studiesare part of medical research and involve people like you

1 H NMR (400 MHz, DMSO-d 6 ) 12.31 (s, 1H), 10.99 (s, 1H), 7.69 (s, 1H), 7.607.54 (m, 2H), 7.40 (t, J = 3.3 Hz, 1H), 6.72 (d, J = 4.5 Hz, 1H), 5.13 (dd, J = 13.1, 5.0 Hz, 1H), 4.444.22 (m, 3H), 4.18 (d, J = 15.7 Hz, 1H), 4.05 (d, J = 6.8 Hz, 2H), 3.77 (s, 1H), 3.68 (d, J = 6.0 Hz, 2H), 3.28 (s, 2H), 3.032.96 (m, 1H), 2.932.87 (m, 1H), 2.73 (s, 1H), 2.682.53 (m, 3H), 2.492.42 (m, 1H), 2.01 (d, J = 11.8 Hz, 1H), 1.80 (d, J = 12.0 Hz, 2H), 1.60 (s, 1H), 1.461.32 (m, 1H), 1.18 (d, J = 6.2 Hz, 9H)

65,66,134 The combined cross-reactivity and sequence similarity suggest molecular mimicry and allude to autoimmune mechanisms resulting in gluten-related brain conditions