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In contrast, health hazards associated with long-term environmental exposure to low concentrations of lead have been reported steadily

It is naturally produced in the liver and plays a critical role in supporting the immune system, detoxifying the body, and protecting cells from oxidative stress and damage

Further studies have established that APR-246 can also trigger p53-independent cell death in several solid cancers, suggesting that besides p53, other cellular targets might be involved in APR-246 effect [56]