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Studies show that between 50% to 98% of injected B12 is found in the urine just 48 hours after the injection is administered, meaning it may have a half-life of up to 24 hours

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The American Diabetes Association (ADA) recommends considering periodic measurement of vitamin B12 levels in patients with type 2 diabetes taking metformin, particularly those with anemia or peripheral neuropathy, though no specific monitoring interval is specified

Acral, targetoid papules, consisting of three distinct concentric zones, are the hallmark lesions of this disease