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Manfredini, F

10.2165/00003088-199937060-00004 Clin

Lower extremity arterial disease in type 2 diabetes mellitus: metformin inhibits femoral artery ultrastructural alterations as well as vascular tissue levels of AGEs/ET-1 axis-mediated inflammation and modulation of vascular iNOS and eNOS expression

In comparison, previous studies reported the use of Irinotecan, an FDA approved SN prodrug, at higher total doses ranging from 150 mg/kg to 400 mg/kg in less than four weeks 63,64,65,66