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When dysbiosis occurs, there is a decrease in HBD-2 levels, resulting in a rise of pathogenic bacteria in the vaginal area.The production of toxins and the induction of reactive oxygen species (ROS) by these bacteria lead to oxidative stress ( Gardnerella vaginalis and Atopobium vaginae ) and CXCL10 levels

The flies solely administered with L-DOPA performed better during initial exposure after which their progress declined, consistent with the reported pattern of wearing-off in L-DOPA administered PD patients 39,55

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