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doi: 10.3389/fvets.2023.1220213 Received 15 May 2023 Accepted 17 July 2023 Published 10 August 2023 Volume 10 - 2023 Edited by Huansheng Yang, Hunan Normal University, China Reviewed by Dan Yi, Wuhan Polytechnic University, China

Therapeutic implications Nrf2 Activators and NLRP3 Inhibitors as Therapeutic Agents in PD Nrf2 activators and NLRP 3 inhibitors have shown encouraging neuroprotective effects in preclinical models of PD

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Dysregulation will persist to enhance autoreactive T cell activation and lead to disease progression and exacerbation ( Changes in the gut microbiota can significantly impact the production of short-chain fatty acids (SCFAs) and other metabolites which in turn modulate systemic inflammation and immunity