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The chaperone function of Tsa1 prevents the accumulation of misfolded ribosomal proteins under reductive stress, which occurs when Tsa1 is present in the cytoplasm (Dauplais et al., 2021

De novo mutationsincluding copy number variations and gene-disrupting mutationscontribute to approximately 3040% of cases

Non-segmental vitiligo is the most common type, characterized by symmetrical bilateral depigmented macules, an unpredictable course and activity that increases in size over time, and is associated with autoimmune diseases

Furthermore, CLE supplementation led to a significant increase in plasma Trx1, SIRT1, and Nrf2 levels, and a significant reduction in TBP2 and NF-B p65 subunit concentrations