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Beyond editing, strategies are being developed to selectively remove large portions of mutated mtDNA by reconstituting double-strand break repair pathways within mitochondria, potentially eliminating deletion-bearing genomes (171)

This mechanism increases intracellular concentrations of both NAD+ and SAM, two fundamental molecules that regulate cellular energy expenditure, mitochondrial function, and epigenetic modifications

Other indirect evidence also comes from the coordinated response of enzyme activities and corresponding gene expression that is often observed in response to stress

Particularly, some sedative and analgesic anesthetics have been widely concerned as treatment methods to reduce oxidative stress and protect important organ functions