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Table 5 Natural compounds that modulate Nrf2 signaling

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Under normal conditions, glial cells become activated in response to danger signals by releasing pro-inflammatory cytokines (TNF-, ILs, and IFN-), and nitric oxide as a defense mechanism, but excessive or prolonged activation becomes damaging (Tjalke et al., 2017)

In brief, hPSCs were plated at a density of 5000 cells/well in a 24-well plate in mTeSR1 medium (Stem Cell Technologies, Vancouver, BC, Canada) + 10 M Y27632 (LC Laboratories, Woodburn, MA) on glass plates (LabTek) coated with 3% GelTrex (Thermo Fisher Scientific, USA) (Day-3)