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Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

This system mediates the exchange of extracellular cystine for intracellular glutamate

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When mitochondrial depolarization and proteasome-dependent rupture of the outer membrane occur, PHB2 binds the autophagosome membrane-associated protein LC3 via the LC3 interaction region structural domain (Fig