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described a potent relaxant property of berberine on tracheal smooth muscle mediated through histamine (H1) receptor antagonism, along with inhibition and nitric oxide production and COX pathways (Saadat et el., 2019)

Collectively, these observations indicate that, despite their similar BMI, obese subjects with low IGF-1 levels are markedly more predisposed to have multiple metabolic abnormalities, such as increased adiposity, inflammation, dyslipidemia and hyperuricemia than subjects in the standard IGF-1 range