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Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: long-term survival analysis of the DESTINY-breast03 trial

The secreted IGF-1 binds to IGF-1R on matrix keratinocytes, initiating a signaling cascade through two parallel pathways: PI3K/Akt pathway: IGF-1R activation phosphorylates PI3K, which activates Akt (protein kinase B)