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Importantly, in the patients bearing tumors with NRF2-KEAP1 alteration a significantly increase in expression of NRF2 target genes was observed, such as NQO1, and the enzymes responsible for GSH synthesis, GCLC and GCLM, which indicates that GSH levels are also higher (Fig

Major limitations of this observation include potential underreporting of cases due to mild symptoms or lack of awareness

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Daily Protocol: 1 to 2 mg subcutaneous injection once daily Alternate Protocol: 2 to 3 mg subcutaneous injection three times weekly Cycle Length: 8 to 12 weeks on Rest Period: 4 to 6 weeks off between cycles Cycles Per Year: 2 to 3 cycles recommended Injection Sites: Abdomen, outer thigh, or upper arm with rotation Cycling Recommendations Research suggests running GHK-Cu in cycles of 8 to 12 weeks followed by rest periods of 4 to 6 weeks