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Some patients, particularly those receiving single-dose formulations like Gel-One, may experience significant relief in as little as 3 weeks

First, stomach acid separates B12 from the protein it's bound to in food

While mild soreness at the injection site is possible, it typically resolves within a day or two

However, patients on thyroid hormone replacement (levothyroxine) should monitor symptoms closely, as improved methylation can affect thyroid hormone conversion (T4 to T3)