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Butyrate promotes the repair and maintenance of the intestinal mucosal barrier, enhancing the expression of tight junction proteins such as Occludin, thereby reducing intestinal permeability and preventing the invasion of pathogenic microorganisms and harmful substances [438]

Neuron 103(4):627641

While high-dose oral tablets (1,000 mcg+) can work for some via "passive diffusion," the IV route bypasses the entire digestive system

A Second C-Reactive Protein (CRP) Test to Detect Inflammatory Burst in Patients with Acute Bacterial Infections Presenting with a First Relatively Low CRP