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Gu Y, Li J, Li Y, Song L, Li D, Peng L, et al

Various physical and/or psychological changes sometimes precede the onset of a migraine headache by a few hours to a few days

A clean cloth or towel must be placed between the heat pack and the skin to avoid skin damage, and application time should be limited to 20 minutes with a break of at least 2 hours before reapplying the heat pack

The connection between the amygdala and prefrontal cortex is what keeps our behavior in check and allows us to make healthy choices (it also helps us make choices that save our lives in other ways, like not stepping too close to an edge or not hitting someone when were angry)