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Description

Nature Chemical Biology

Our data suggest that choline can promote liver health by maintaining cholesterol homeostasis.10 Choline induces glucose and insulin intolerance in Pemt(-/-) mice through modulating plasma glucagon and its action in liver.11 Choline supplementation decreased the concentration of liver triacylglycerol during the first 4 wk after parturition

The phenotypic outcome is a shift toward higher energy expenditure and improved adipose/lipid profiles without the catabolic loss of lean tissue commonly seen with severe caloric restriction