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50 Spontaneous intramolecular rearrangement and elimination of the carbamate group at C10 of mitomycin C results in a second alkylation reaction with the opposite strand of DNA to induce cytotoxic 1,2-GG interstrand crosslink lesions (Figure 7)

Conversely, under specific conditions, glutaredoxins which depend on glutathione for their activity can also reduce oxidized thioredoxins

Tetracyclines are also typically prescribed to treat tickborne rickettsial infections such as Ehrlichia, Anaplasma, and Rocky Spotted Mountain Fever