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Future research should employ pragmatic and innovative strategies: first, leveraging real-world data through nested case-control studies linking dietary supplement usage with cancer registries to generate preliminary epidemiological insights into the association between long-term L-carnitine use and HCC incidence in MASLD populations

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Excessive androgens, on the one hand, induce disorders of lipid metabolism by promoting visceral fat deposition, enlarging adipocytes, enhancing inflammatory response, macrophage infiltration, and apoptosis in women ( In summary, evidence from pre-clinical and clinical studies reveal the consistent regulatory roles of androgens/AR in glucose and lipid metabolism, with clear sex-dependent differences ( Figure 1 )

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