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Additionally,PA possesses immune-regulating properties and induces cellular autophagy, which further contributes to its anti-cancer mechanisms

Stimulation of mouse organoids Before stimulation, organoids were allowed to establish for 6 days

Noteworthy, tumor progression requires the development of new vessels and such aberrant vessels are responsible for the disruption of the BBB and then, changing into blood-tumor barrier (BTB)

Together with pericytes, astrocytes are an essential component of the bloodbrain barrier (BBB), which selects and transports molecules from the bloodstream, and allows for the transfer of nutrients to neurons (Figure 1B)